Roles of Emx2 in Odorant Receptor Gene Expression and Olfactory Sensory Neuron Axon Growth
نویسندگان
چکیده
OF DISSERTATION Jeremy Colin McIntyre
منابع مشابه
Lhx2 Determines Odorant Receptor Expression Frequency in Mature Olfactory Sensory Neurons
A developmental program of epigenetic repression prepares each mammalian olfactory sensory neuron (OSN) to strongly express one allele from just one of hundreds of odorant receptor (OR) genes, but what completes this process of OR gene choice by driving the expression of this allele is incompletely understood. Conditional deletion experiments in mice demonstrate that Lhx2 is necessary for norma...
متن کاملBIG-2 Mediates Olfactory Axon Convergence to Target Glomeruli
Olfactory sensory neurons expressing a given odorant receptor converge axons onto a few topographically fixed glomeruli in the olfactory bulb, leading to establishment of the odor map. Here, we report that BIG-2/contactin-4, an axonal glycoprotein belonging to the immunoglobulin superfamily, is expressed in a subpopulation of mouse olfactory sensory neurons. A mosaic pattern of glomerular arran...
متن کاملA critical period defined by axon-targeting mechanisms in the murine olfactory bulb.
The olfactory system remains plastic throughout life because of continuous neurogenesis of sensory neurons in the nose and inhibitory interneurons in the olfactory bulb. Here, we reveal that transgenic expression of an odorant receptor has non-cell autonomous effects on axons expressing this receptor from the endogenous gene. Perinatal expression of transgenic odorant receptor causes rerouting ...
متن کاملSilencing of Odorant Receptor Genes by G Protein βγ Signaling Ensures the Expression of One Odorant Receptor per Olfactory Sensory Neuron
Olfactory sensory neurons express just one out of a possible ∼ 1,000 odorant receptor genes, reflecting an exquisite mode of gene regulation. In one model, once an odorant receptor is chosen for expression, other receptor genes are suppressed by a negative feedback mechanism, ensuring a stable functional identity of the sensory neuron for the lifetime of the cell. The signal transduction mechan...
متن کاملA model for axon navigation based on glycocodes in the primary olfactory system.
In rodents, primary olfactory sensory neurons reside in the psuedostratified olfactory neuroepithelium lining the caudal nasal cavity. Each neuron expresses a single odorant receptor and all neurons expressing the same receptor are typically located in one of four bands of neuroepithelium lining the nasal cavity (Buck and Axel, 1991; Vassar et al., 1993, 1994). While there are ~1000 different o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016